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As previously mentioned, the CNS-1 model may be used to study the model nude caution ak from tj properties of tumour cells. In the presence of CNS-1 tumour, endothelial cells undergo hyperplasia and display a pseudo-palisading pattern accompanying necrosis Kerbel,both of which are indications of increased angiogenesis mimicking human GBM Beranek, A study of pure and mixed glioma cell line tumours. Immunohistopathological and neuroimaging characterization of murine orthotopic xenograft models of glioblastoma multiforme recapitulating the most salient features of human disease. GL also displays endothelial thickening based on increased CD31 expression [30].

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